Small Angle X-ray Scattering (SAXS); Biophysical Chemistry.
Using SAXS, we are trying to understand the shape-function relationship of proteins and their complexes. Prime interests include actin assembly regulating protein- gelsolin, antibodies, proteins involved in kidney’s filtration system, growth differentiation factors and viral entry proteins. Scattering based models are supplemented with other biochemical and/or biophysical data to understand the biology. Recently, using the information, group is foraying into the area of developing rapid diagnostic kits which will aid in exploring therapeutic potential of molecules mentioned above.
- Arif, E., Sharma, P., Solanki, A., Mallik, L., Rathore, Y. S., Twal, W. O., Nath, S. K., Gandhi, D., Holzman, L. B., Ostap, E. M., Ashish, and Nihalani, D. (2016) Mol Cell Biol 36, 1639-1654
- Sharma, P., Verma, N., Singh, P. K., Korpole, S., and Ashish. (2016) Sci Rep 6, 22475.
- Rathore, Y. S., Dhoke, R. R., Badmalia, M., Sagar, A., and Ashish. (2015) J Phys Chem B 119, 6101-6112.
- Rehan, M., Sagar, A., Sharma, V., Mishra, S., Ashish, and Sahni, G. (2015) J Phys Chem B 119, 13271-13277.
- Solanki, A. K., Rathore, Y. S., Badmalia, M. D., Dhoke, R. R., Nath, S. K., Nihalani, D., and Ashish. (2014) J Biol Chem 289, 34780-34800.