Medicinal Chemistry, Computational Drug Discovery, Molecular Dynamics and Chemical Biology.
My current research focus is to understand the roles that various enzymes (bacterial and mammalian) and biomolecules (especially RNA) play in physiological and pathological processes and use this knowledge to identify small molecule therapeutics for targeting human disease. To achieve these goals, our group develops and applies new technologies at the interface of chemistry and biology, ascribing to the philosophy that the most significant biomedical problems require creative multidisciplinary approaches for their solution. In particular, utilize a multidisciplinary approach to explore mechanisms of disease pathology and identify chemical probes and lead molecules for both disease diagnosis and treatment. with particular emphasis on the development of small molecules therapeutics for tuberculosis, epigenetic proteins, and RNA related diseases.
- Parkesh, R., Bhutani, I., Madathil, R. (2016) Structure, shape and electrostatic based virtual screening to discover small molecule therapeutics. Invited Book Chapter. Austin Publishing House, USA.
- Priyanka, A., Solanki, V., Parkesh, R. and Thakur, K. G. (2016), Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture. Proteins 84, 1558–1563.
- Loharch, S., Bhutani, I., Jain, K., Gupta, P., Sahoo, D.K., Parkesh, R. (2015) EpiDBase: a database for small molecule modulators of Epigenetic Landscape. Database (Oxford). pii: bav013.
- Dkhar, H. K., Gopalsamy, A., Loharch, S., Kaur, A., Bhutani, I., Saminathan, K., Bhagyaraj, E., Agrawal, P., Parkesh, R., and Gupta, P. (2015) Discovery of Mycobacterium tuberculosis GlgB Inhibitors By Structure and Ligand Based Virtual Screening. J Biol Chem. 290, 76-89.
- Mehta, A., Sonam, S., Gouri, I., Loharch, S., Sharma, D. and Parkesh, R. (2014) SMMRNA:a database of small molecule modulators of RNA. Nucleic Acids Res. 42, D132-41.