Write-up of research and development interests/focus, past and present goals:
Research Focus: Immunoregulation and Gene regulation.
The work ongoing in the laboratory focuses on two general aspects. The first entails investigation of the molecular mechanisms that regulate dendritic cell (DC) activation versus tolerance in response to various immunomodulators and cytokines. The second key area of our research is to define the regulatory mechanisms associated with the expression of costimulatory molecules and inhibitory receptors on DCs. We are currently assessing the physiological relevance of the outcome of these projects in the context of tumor immunobiology and infectious diseases such as visceral leishmaniasis to identify specific drug target(s) for immunotherapy.
In brief, our ongoing work involving cell signaling and gene regulation addresses both fundamental and applied aspects of immunoregulation of DCs in the context of infectious and innate immune diseases.
Selected list of Publications and Patents:
Ravindra Gujar, Neeraj Maurya, Vinod Yadav, Mamta Gupta, Saurabh Arora, Neeraj Khatri and Pradip Sen (2016). c-Src suppresses dendritic cell antitumor activity via T cell Ig and mucin protein-3 receptor. Journal of Immunology. 197 (5): 1650-62.
Neeraj Maurya, Ravindra Gujar, Mamta Gupta, Vinod Yadav, Saurabh Verma and Pradip Sen (2014). Immunoregulation of Dendritic Cells by the Receptor T cell Immunoglobulin and Mucin Protein-3 (TIM-3) via Bruton's Tyrosine Kinase and c-Src. Journal of Immunology. 193 (7): 3417-25.
Eshu Singhal, Prakash Kumar and Pradip Sen (2011). A novel role for Bruton’s tyrosine kinase in hepatocyte growth factor mediated immunoregulation of dendritic cells. Journal of Biological Chemistry. 286(37): 32054-32063.
Eshu Singhal and Pradip Sen (2011). Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway inhibits dendritic cell activation by blocking IkB kinase activity. International Journal of Biochemistry and Cell Biology. 43: 1134-1146.
Arun Kumar Haldar, Vinod Yadav, Eshu Singhal, Kamlesh Kumar Bisht, Alpana Singh, Suniti Bhaumik, Rajatava Basu, Pradip Sen and Syamal Roy (2010). Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation. PLoS Pathogens 6(5), 1-21, e1000907. (Corresponding author: Pradip Sen).
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