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Name:
Dr. Balvinder Singh
Expertise:
Molecular Modeling and Simulations; Bioinformatics.

Contact Address:

Bioinformatics Centre,
Institute of Microbial Technology,
Sector 39A,
Chandigarh-160 036, India.
Email: bvs@imtech.res.in,
Phone number: +91-172-2636680-94 (Extn. 3105); +91-172-2690557 (Direct)
FAX: +91-172-2690632, 2690585.


Write-up of research and development interests/focus, past and present goals:

Our current interests include protein sequence analysis, protein structure prediction, its annotation and biomolecular modeling with emphasis on comparison of force fields employed to carry out simulations/simulations. We are particularly developing strategies to derive rules for protein-DNA interactions by analysis of existing complex structures and their simulations. We are also involved in modeling of proteins so as to facilitate their structural and functional annotation using in silico biology tools.


Significant recognition: Awards, fellowships, international funding of distinction, technologies transferred/licensed etc.:

  • DBT Overseas Associateship Award 2006-2007
  • Senior Research Fellow (1992-1995), Council of Scientific & Industrial Research, New Delhi.
  • National Eligibility Test (CSIR-UGC), 1992.
  • Graduate Aptitude Test Examination (GATE), 1991.

Selected list of Publications and Patents:

  • Kaur R, Ahuja S, Anand A, Singh B, Stark BC, Webster DA, Dikshit KL. (2008) Functional implications of the proximal site hydrogen bonding network in Vitreoscilla hemoglobin (VHb): Role of Tyr95 (G5) and Tyr126 (H12). FEBS Lett., 582(23-24):3494-500.


  • Kapoor D, Kumar V, Chandrayan SK, Ahmed S, Sharma S, Datt M, Singh B, Karthikeyan S, Guptasarma P. (2008)  Replacement of the active surface of a thermophile protein by that of a homologous mesophile protein through structure-guided 'protein surface grafting' Biochim Biophys Acta. 1784(11):1771-6.


  • Saxena R, Kanudia P, Datt M, Dar HH, Karthikeyan S, Singh B, Chakraborti PK. (2008) Three consecutive arginines are important for the mycobacterial peptide deformylase enzyme activity. J Biol Chem. 283(35): 23754-64.


  • Bachhawat N, Singh B. (2007) Mycobacterial PE_PGRS Proteins Contain Calcium-Binding Motifs with Parallel beta-roll Folds. Genomics Proteomics Bioinformatics. 5:236-41.


  • Singh, B (2004) PepBuild: A web server for building structure data for a peptide/protein. Nucleic Acid Res., 32:W559-W561


  • Luthra-Guptasarma, M. & B. Singh (2004) HLA-B27 lacking associated beta2-microglobulin rearranges to auto-display or cross-display residues 169-181: a novel molecular mechanism for spondyloarthropathies. FEBS Lett., 575:1-8.


  • Nandel, F.S., N. Malik, B. Sinqh and D.V.S. Jain (1999). Conformational structure of peptides containing dehydroalanine: Formation of beta-bend ribbon structure. Int. J. Quant. Chem. (Biophysics), 72: 15-23.


  • Nandel, F.S., R. Verma, B. Sinqh and D.V.S. Jain (1998). Mechanism of hydration of urea and guanidium ion: A model study of denaturation of proteins. Pure &. Appl. Chem., 70: 659-664.


  • Nandel, F.S., B. Sinqh & A. Saran (1992). Conformational structure of the tetrapeptide Boc-Aib-­Leu-Leu-Aib-OMe- the central fragment of the nonapeptide antibiotic Leucinostatin A. Int. J. Quan. Chem., 42:1669-79.


Patent:


  • NF No. 0215NF2006/IN

    Title: Creation of an active stable chimeric protein through transplantation of the entire active surface of a protein onto its structural homolog.

    Inventors:  Divya Kapoor; Sanjay Kumar Chandrayan; Shubbir Ahmed; Swati Sharma; Manish Datt;

    Balvinder Singh; S Karthikeyan

    Application No. 2411DEC2006


Present group members:

  • Manish Datt
  • Ruchi Sachdeva
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