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Name:
Dr. C.R. Suri
Expertise:
Biosensor Development

Contact Address:

C Raman Suri, PhD

Institute of Microbial Technology

Sector 39-A

Chandigarh 160036, INDIA

Phone: 0091-172-6665225; 0091-9878021958 (M)

Fax: 0091-172-2690632 / 2690585

E-mail: raman@imtech.res.in


Write-up of research and development interests/focus, past and present goals:

Research Activities:  Biosensor Development

  • Development of enzymatic and antibody based biosensors for clinical / environmental applications

  • Synthesis of nanoparticles (inorganic, polymer and semiconductor) for immunodiagnosis and therapeutic applications.

  • Design and development of antibody based immunobiosensors for monitoring various organic/inorganic/biomolecular substances.

Expertise and Synergistic Activities:

  • Generation of specific antibodies (IgG and IgY types) and aptamers against toxins (pesticides, aflatoxin etc),  narcotic drugs (heroin, morphine, cocaine etc.) and surface antigens (outer membrane protein, biomarkers etc) for clinical diagnosis.

  • Optimization of biomolecular immobilization techniques for a stable coupling of the antibodies to the transducer surface without comprising their biological activity.

  • Characterization of the bio-interface upto the molecular resolution by different physical techniques, such as Scanning Electron Microscope (SEM), Scanning Tunneling Microscope (STM), Atomic Force Microscopes (AFM), Ellipsometer etc..

  • Development and standardization of  immunobiosensors systems (Optical, Microgravimetric, Micromechanical, Microfluidic and Dipstick)

  • Stability analysis of immobilized enzyme/antibody for biosensor probes and

  • Synthesis of nanoparticles (inorganic, semicoductor  and polymer based ) for immunodiagnosis and therapeutic applications.

Visiting Professorship/Scientist:

  • North-Western University, Illinois, USA

  • EPFL, Lausanne, Switzerland

  • NTU, Singapore



Fellow:

  • Institute of Hospital Engineering, India.

  • DAAD, Germany



Member Editorial Board:

  • Member-Editorial Board, J. Food, Agri. and Environment, Helsink, Finland.

  • Member-Editorial Board, Research Journal of Chem. and Environment.

  • Member-Editorial Board, Panjab University Research Journal of Science, Chandigarh, India.


Membership:

  • Nodal officer (Chairman): Biomarker/Biosensor group,  Department of Biotechnology (Govt. of India)

  • Member- Task Force (Expert  Advisory Committee) (1) Conducting Polymer and Biosensors DST India (2) Bioengineering, DBT India and (3) Low cost sensors, ICMR, India

  • Joint Secretary, Biosensor Society of India.

  • Life Member, Biosensor Society of India

  • Life Member of Biophysical Society of India.

  • Member-selection committees,  IIT, CSIR and Panjabi University.


Teaching Experience:


Teaching  M.Tech students of Panjab University, Chandigarh and PhD students (JNU, Delhi) at IMTECH Chandigarh for fulfilling their partial requirement to obtain M.Tech and PhD degrees respectively.


Selected list of Publications and Patents:

Recent publications (Last 5 years)

Yogesh Nangia, Nishima
Wangoo, Saurabh Sharma, Jin-Song Wu, Vinayak Dravid,   G S Shekhawat, and C Raman Suri*
(2009)
Facile biosynthesis of phosphate capped gold
nanoparticles by a bacterial isolate Stenotrophomonas maltophilia
Appl. Phys. Lett
.  94, 233901.



 



I. Putu
Mahendra Wijaya,  Sonu Gandhi, Tey Ju
Nie, Nishima Wangoo, Isabel Rodriguez, G. Shekhawat, C. Raman Suri*,
and Subodh G. Mhaisalkar* (2009) Protein/carbon nanotubes interaction: The effect of
carboxylic groups on conformational and conductance changes.  Appl. Phy. Letter, 95, 073704 



 



Fazlurrahman*, M. Batra*,
J. Pandey, C.R. Suri and R.K. Jain (2009) Isolation and characterization of an
atrazine-degrading Rhodococcus sp. strain MB-P1 from contaminated soil.  Letters in Applied Microbiology.  49 721–729



 



Sonu Gandhi, Neena Caplashb,  Prince Sharma, C. Raman
Suri
* (2009). 
 Strip-based immunochromatographic assay using specific egg yolk
antibodies for rapid detection of morphine in urine samples.
 Biosensors and Bioelectronics. 25,  502–505.



 



Robin C. Boro, K. Vikas Singh and C. Raman Suri* (2009). Characterization of Hapten-Protein Conjugates:
Antibody Generation and Immunoassay Development for Chlorophenoxyacetic Acid
Pesticides
J. AOAC Int. 92(6), 1773 .



 



I
Putu Mahendra Wijaya, Tey Ju Nie, Sonu Gandhi, Robin Boro, Alagappan
Palaniappan, Goh Wei Hau, Isabel Rodriguez , C. Raman Suri, Subodh G.
Mhaisalkar (2010).  Femto Molar Detection
of 2, 4-dichlorophenoxyacetic acid Herbicides via Competitive Immunoassays in a
Microfluidic Based Carbon Nanotube Liquid Gated Transistor. Lab on Chip 10,
634-638.



 



K. Vikas Singh, Pooja Khanna, C. Raman Suri*, and Mohan L. Garg*
(2010) Structural and Immunogenic Effects of Multiple Hapten Loading on Carrier
Protein. J AOAC Int 93 (1) 59.



Raghuraj S. Chouhan, Kumar Vikash S. Rana, Raman C. Suri,
Ravindranathan K. Thampi, and Munna S. Thakur (2010) Trace-Level Detection of
Atrazine Using Immuno-chemiluminescence: Dipstick and Automated Flow Injection
Analyses Formats.  J AOAC Int. 93 (1)
28.



 
Sanjay Rawat, C. Raman  Suri Debendra K. Sahoo (2010) Molecular mechanism of polyethylene glycol mediated stabilization of protein. BBRC 392, 561-566.
 


J. N. Tey, S. Gandhi, I. P.
M. Wijaya, Al. Palaniappan, J. Wei, I. Rodriguez, C. Raman  Suri and S. G. Mhaisalkar (2010). Direct
Detection of Heroin Metabolites using a Carbon Nanotubes Liquid Gated Field
Effect Transistor based Competitive Immunoassay". SMALL (Accepted;
available online) 



Priyanka Sharma, Adity
Chopra, Swaranjit Singh  and C Raman
Suri  (2010)
Efficient biotransformation of herbicide diuron by bacterial strain Micrococcus
sp. PS-1. Biodegradation Journal  21, 979-987..



 



Nishima wangoo, Jyotsna Kaushal, K K Bhasin and C
Raman Suri (2010)
Zeta potential
based colorimetric immunoassay for the direct detection of diabetic marker
HbA1c using gold nanoprobes Chem.
Comm.
, 46, 5755 - 5757.



 
Priyanka Sharma, Sonu Gandhi, Adity Chopra, N. Sekar and C Raman Suri  (2010) Fluoroimmunoassay based on suppression of fluorescence self-quenching for ultra-sensitive detection of herbicide diuron  Anal. Chimica  Acta 676, 87-92 
 
Priyanka Sharma  and C Raman Suri (2011) Biotransformation and biomonitoring of phenylurea herbicide diuron. Bioresource Technology   102, 3119–3125.
 


Sok Yee Yew,Gajendra Shekhawa, Nishima
Wangoo,Subodh Mhaisalkar, C. Raman Suri, Vinayak P Dravid and Yeng Ming Lam
(2011) Design of single peptides for self-assembled conduction channels.
 Nanotechnology (Accepted for
publication)



 



Robin Boro, Jyotsna Kaushal, Yogesh
Nangiar, Nishima Wangoo  and C Raman Suri
(2011) Gold nanoparticles catalyzed chemiluminescence immunoassay for detection
of herbicide 2,4-dichlorophenoxyacetic acid. Analyst 136, 2125



 



Priyanka Sharma, Kavita Sablok, Vijendra
Bhalla, and C raman Suri (2011). A novel disposable electrochemical
immunosensor for phenyl urea herbicide Diuron. 
Biosensors and Bioelectronics,
26,  4209–4212



 



S.
Thakur, Sonu Gandhi, A. K. Paul, C. Raman Suri (2011). A Flow Injection
Immunosensor for the Detection of Atrazine in Water Samples.
Sensors & Transducers Journal, 131, 91-100



 



Arun Chauhan, 
S. Zubiar, S. Tuhail, A Sherwani, C. R. Suri, A Azam and M. Owais
(2011). Fungus mediated biological synthesis of gold nanoparticles: Poteintial
in detection of lever cancer.  International Journal of Nanomedicine
2011:6 1–15.



 



V Bhalla, Sandro Carrara,
Priyanka Sharma, Yogesh Nangia, C. Raman Suri (2012)
 Gold nanoparticles mediated
label-free capacitance detection of cardiac Troponin.  Senso
rs
and Actuators B
161,  761-768



 



Al. Palaniappan, W.H.
Goh, U.H. Yildiz, B. S. Priyanka, C. Raman Suri, S.G. Mhaisalkhar, B. Liedberg
(2012
)  Detection of low molecular
weight compounds using carbon nanotube grafted resonators
  Sensors
and Actuators B
, 161, 689-696



 



Richa Rastogi, Navneet
Dhindsa, C. Raman Suri, B D Pant, S.K. Tripathi, Inderpreet Kaur (2012)  Interfacing of DNA with Carbon Nanotubes for
Nanodevice Applications. Materials Chemistry and Physics, 135, 268-276.



 



Priyanka Sharma, V. Bhalla,
Satish Tuteja, Manil Kukkar and C Raman Suri (2012). Rapid extraction and
quantitative detection of herbicide diuron in surface water by
hapten-functionalized carbon nanotubes based electrochemical analyzer. Analyst 137, 2495-2502.



 



Nishima Wangoo, Gajendra
Shekhawat,  Jin-Song Wu,  C. R. Suri, K. K. Bhasin,  Vinayak Dravid.  Green synthesis and characterization of size
tunable silica-capped gold core–shell nanoparticles. J Nanopart Res (2012) 14:1011



 



Vijayender Bhalla, Priyanka
Sharma, Satish K. Pandey, C. Raman Sui (2012) Impedimetric label-free
immunodetection of phenylurea class of herbicides.  Sensors
and Actuators B
171– 172. 1231– 1237



 



Yogesh
Nangia, Bipul Kumar, Jyotsna K. and C Raman Suri (2012). Palladium@gold
bimetallic nanostructures as peroxidase mimic for development of sensitive
fluoroimmunoassay. Aanl. Chim. Acta
751,  140– 145



Yogesh Nangia, V.
Bhalla, Bipul Kumar and C. Raman Suri (2012). Electrochemical stripping
voltammetry of gold ions for development of ultra-sensitive immunoassay for
chlorsulfuron. Electrochemistry Communications 14, 51-54.



Priyanka S.,  Adity Chopra & Shilpa Chaudhary & C.
Raman Suri (2012) Bio-nanomechanical Detection of Diabetic Marker HbA1c.  BioNanoSci.
2:179
184



 



Sanjay Rawat, C
Raman Suri and D. Sahoo (2012) Molecular mechanism of improved structural
integrity of protein in polymer based microspheres delivery system. Molecular Pharmaceutics 9, 2403-2414.



 



Priyanka S, Vijayender Bhalla, Vinayak Dravid,
Gajendera Shekhawat, Jinsong-Wu, E. Senthil Prasad and C. Raman Suri (2012)
Enhancing electrochemical detection on graphene oxide-CNT  nanostructured electrodes using
magneto-nanobioprobes Scientific Reports
(Nature Publication), 2, 877
doi:10.1038/srep00877



 



Priyanka S, V Bhalla, E Senthil Prasad, V Dravid, G
Shekhawat, and C. Raman Suri (2012). Enhancing graphene/CNT based
electrochemical detection using magneto-nanobioprobes. Nature Protocol Exchange doi:10.1038/protex.2012.059



 



Priyanka S, Satish Tuteja, V. Bhalla, V. Dravid, G Shekhawat and C
Raman Suri (2013)
Bio-functionalized
graphene–graphene oxide nanocomposite based electrochemical immunosensing
. Biosensors and Bioelectronics 39, 99–105.



 



Kavita Sablok, V K
Bhalla, Priyanka, Shilpa
Chaudhary
and
C Raman Suri (2013) Amine
functionalized graphene oxide/CNT nanocomposite for ultrasensitive
electrochemical detection of trinitrotoluene. Journal of Hazardous Materials
248,
322–328



 



Adity Chopra,
Satish Tuteja, K K Bhasin, V K Bhalla and C Raman Suri (2013) CdTe nanobioprobe
based optoelectrochemical immunodetection of diabetic marker HbA1c. Biosensors and Bioelectronics, 44, 132-135



 



Priyanka S, Manil Kukkar, A Ganguli, Aman Bhasin and C. Raman Suri (2013).
Plasmon
enhanced fluoro-immunoassay using egg yolk antibodies for ultra-sensitive
detection of herbicide diuron.
Analyst, 138, 4312.



 



Adity
Chopra, Sanjay Rawat, Vijayender Bhalla and C. Raman Suri (2014) Point-of-Care
Amperometric Testing of Diabetic Marker (HbA1c) Using Specific Electroactive Antibodies.
Electroanalysis, 26, 1-4.



 



Satish
K Tuteja
, Priyanka, Vijayender
Bhalla
, Akash Deep, A. K. Paul
and C Raman
Suri
(2014). Graphene-gated biochip for the detection of cardiac marker
Troponin I.
  Anal.
Chim. Acta
, 809, 148-154.



 



Satish
K. Pandey
,  A.
C. Vinayaka
, D. B.
Rishi
, Praveen
Rishi
and  C.Raman
Suri
(2014).



 Immuno-fluorescence based Vi capsular polysaccharide
detection for specific recognition of Salmonella enterica serovar Typhi in
clinical samples
. Anal. Chim. Acta, 841,
51-57.



 



Priyanka,
Munish Shorie, V. Bhalla, Preeti Pathania and C. Raman Suri (2014).
Nanobioprobe mediated DNA aptamers for explosive detection. Chem Commun.
50, 1080-1082.



 



Priyanka
S
., Munish
Shorie
, Preeti
Pathania
, Shilpa
Chaudhary
, Kuldeep
Kumar Bhasin
, Vijayender
Bhalla
, C Raman
Suri
(2014).  A hybrid aptamer-antibody linked FRET based detection of
trinitrotoluene.
Analytical Chemistry, 86, 7200-7204.



 



Satish
 Tuteja,  Priyanka S.,  Akash Deep, Richa Rastogi, A. K. Paul and C.
Raman Suri (2014). Biofunctionalized Rebar Graphene (f-RG) for Label-Free
Detection of Cardiac Marker Troponin I.  ACS
Appl. Mater. Interfaces,
6, 14767-14771.



 



 



 



 



 



Book/Chapters:



1.      Immunosensors for pesticides monitoring. Advances in
Biosensors (Elsevier publication). Eds. APF Turner and BD Malhotra Vol. 5, pp
161-178.



2.      Immunosensor for Pesticide Analysis. Nature News
India (Macmillan Press)



 



Patents:



1.     
Microporous
filtration based dot immunoassay device for method of screening of analytes and
method of use.  Chander Raman Suri, Grish
Chandra Varshney and Manoj Raje  (US Patent No. US 7,419,640).



2.     
An
efficient and improved method for screening of organic molecules by microporous
filtration based dot immunoassay kit. 
Chander Raman Suri, Grish Chandra Varshney and Manoj Raje  (EP Patent No. 159211 B1



3.     
An
efficient and improved method for screening of organic molecules by microporous
filtration based dot immunoassay kit. 
Chander Raman Suri, Grish Chandra Varshney and Manoj Raje  (AU Patent No. 2002348763 B2) .



4.     C.R.Suri, Jasdeep
Kaur,  et al . An immunoconjugate and
process for preparation thereof. European
Patent No. EP 1915616 B1
).



 



 



5.     
A
process for the attachment of hapten to polystyrene for immuno-affinity
applications Inventors:  Chander Raman
Suri, Jasdeep Kaur, Kanwar Vikas Singh, Grish Chandra Varshney and Manoj Raje .
Ref. No. 0049/NF/2003.



6.     
C.R.Suri,
Jasdeep Kaur, et al . A dipstic based immunoassay for pesticide monitoring.
Application file no. 1983DEL2005


Present group members:

Research Fellows
  • Ms. Adity Chopra
  • Mr Satish Tuteja
  • Ms. Shilpa Chaudhary
  • Ms Ruchi

Welcome Trust Fellow: Dr. (Ms) Padma

Nehru Fellow: Dr. Vinayaka, A. 

Research Associate: Dr. (Ms.) Monu Jaryal 

Project Assistant

  • Ms Preeti

Past group members:

  • Dr. Vikas Rana
  • Dr. Kumar Rajesh
  • Dr Robin Boro
  • Dr. (Ms.) Nishima Wangoo
  • Dr. (Ms.) Sonu Gandhi
  • Dr. (Ms.) Priyanka Sharma
  • Dr. Yogesh Nangiar
  • Dr. Sanjay Rawat
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