We are trying to understand structure-function relationship of proteins using biophysical methods mainly NMR, dynamic and electrophoretic light scattering (DLS and ELS), small angle x-ray/neutron scattering (SAXS/SANS). Significant use of molecular modeling methods are also employed to gain visual insight into flexible yet functionally important regions in proteins. Our long-term goal is to employ the solution conformational properties of proteins and their complexes to design minimal versions retaining some function of the native protein.
Topics of Interest and group members
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