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Molecular and systems level understanding of regulatory networks in pathogenic microbes


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 I. Understanding regulatory mechanisms pertaining to microbial pathogenesis

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Part A:  Understanding the network of transcriptional and translational regulation

  • Global regulators contributing to M. tuberculosis pathogenesis
  • Exploring NME- pathway of M. tuberculosis and riboflavin biosynthesis pathway of Vibrio as anti-bacterial target
  • Cross-talk  of different M. tuberculosis hemoglobins with cellular components: implications on pathogenesis
  • Glycosylation of proteins as PTM and its relevance in M. tuberculosis pathogenesis

Part B: Phenotypic switching-assisted drug resistance

  • Genetic pathway of M. tuberculosis involved in  drug- resistant biofilm formation
  • Molecular basis of amphotericin B resistance in biofilm forming cells of C. albicans: genes that contribute to AmpB resistance
  • Protein kinase signaling cascade and its contribution to antimicrobial resistance, pathogen survival and virulence of multi-drug resistant  Acinetobacter baumannii
  • Exploring budding yeast as a model for functional exploration of virulence determinants from gut pathogenic bacteria

 

 

II. Dissecting host-pathogen interactions in the context of virulence
 

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  • Host pathways that determine the availability of micronutrients

  • Influence of pathogenic factors on the innate immunity pathways such as authophagy and/or authophagic response

  • Modulation of cytokine profiles by secretory virulence factors

  • Role of endocrine factors in modulation of immune system in the infectious disease

 

 

 

III. Exploring unconventional methods to design and develop novel disease prevention strategies

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The currently available BCG vaccine is one of the most widely used vaccine throughout the world. However, the efficacy of this vaccine is highly variable ranging from 0% in South India to 60% in the Western world. Recently, CSIR-IMTECH has demonstrated that supplementation of BCG with IL-7 and IL-15 substantially improved its protective efficacy by enhancing T-cell memory response. In this proposal, we wish to evaluate prophylactic and therapeutic efficacy of recombinant BCG strains secreting the cytokines IL-7 and IL-15 in animal models and human PBMCs

 

 

 

 

 
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