Venue: CSIR-IMTECH
All are cordially invited to a special scientific lecture by Dr. Tridib Mahata on 3rd
June 2024 at 11:00 AM in the seminar hall, main building. Currently,
Dr. Tridib Mahata is working as a Postdoc fellow in the Department of
Clinical Microbiology and Immunology, School of Medicine, Tel Aviv
University, Israel. He obtained his PhD from CSIR-IICT, Hyderabad.
Title: Investigate phage-bacteria interactions to explore novel bacterial immune systems and phage-derived antimicrobials
Date and Time: 3rd June 2024 at 11 AM
Venue: Seminar Hall, Main Building, CSIR-IMTech
Abstract of the talk:
Bacteriophages
and bacteria engage in a constant arms race, developing defense and
anti-defense systems. Bacteriophages have evolved multiple strategies to
target host metabolic pathways, while bacteria have developed various
defense mechanisms against phage predation. Our research has identified
specific phage-encoded gene products, T5.008 and T5.015, which inhibit
bacterial cell growth by targeting key components of E. coli. T5.008
disrupts the FtsZ ring, inhibiting cell division and granting T5 a
selective advantage (1). T5.015 binds with Uracil DNA glycosylase (Ung)
to selectively nick dUMP-containing DNA, leading to replication blockage
and cell division inhibition (2). These unique mechanisms make T5.008
and T5.015 potential antimicrobial agents. Furthermore, we've discovered
a widespread genetic element characterized by the presence of
Gamma-Mobile-Trio (GMT) proteins, functioning as a mobile bacterial
weapons arsenal. GMT islands are active mobile elements, containing
secreted antibacterial toxins and anti-phage defense systems. This
discovery has allowed us to identify four new anti-phage defense systems
encoded within GMT islands, including a novel immune system with a
nuclease domain that induces cell dormancy upon activation by a phage
capsid protein (3).
Screen Reader Access