Previous research efforts of our laboratory were focused on two important aspects related to the diseases kala-azar and cancer. The first entailed characterization of host immune responses against drug-resistant or susceptible Leishmania parasites, the causative agents of kala-azar. The second research aspect in tumor immunobiology led us to identify c-Src and Bruton’s tyrosine kinase as potential targets for anti-cancer therapy. Efforts are ongoing to identify new receptor(s) mediating Leishmania infection. In addition, our translational activities include development of biosimilar therapeutic monoclonal antibodies for the treatment of autoimmune diseases and cancer. In brief, our ongoing work encompasses both fundamental and applied research on cancer, infectious and autoimmune diseases.

• Md. Naushad Akhtar, Manish Mishra, Vinod Yadav, Manisha Yadav, Ravindra Gujar, Sunaina Lal, Raj Kumar, Neeraj Khatri and Pradip Sen (2020). Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells. PLoS Pathogens 16(12): e1009136.
• Ravindra Gujar and Pradip Sen (2018). Transforming growth factor-b1 impairs lymph node homing of dendritic cells by downregulating C-type lectin receptor-2 expression. Cytokine. 110:39-43.
• Gujar, R., Maurya, N., Yadav, V., Gupta, M., Arora, S., Khatri, N., and Sen, P. (2016) c-Src Suppresses Dendritic Cell Antitumor Activity via T Cell Ig and Mucin Protein-3 Receptor. J. Immunol. 197, 1650-1662.
• Maurya, N., Gujar, R., Gupta, M., Yadav, V., Verma, S., and Sen, P. (2014) Immunoregulation of dendritic cells by the receptor T cell Ig and mucin protein-3 via Bruton's tyrosine kinase and c-Src. J. Immunol. 193, 3417-3425.
• Singhal, E., Kumar, P., and Sen, P. (2011) A novel role for Bruton's tyrosine kinase in hepatocyte growth factor-mediated immunoregulation of dendritic cells. J. Biol. Chem. 286, 32054-32063.
• Singhal, E., and Sen, P. (2011) Hepatocyte growth factor-induced c-Src-phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway inhibits dendritic cell activation by blocking IkappaB kinase activity. Int. J. Biochem. Cell Biol. 43, 1134-1146.
• Haldar, A. K., Yadav, V., Singhal, E., Bisht, K. K., Singh, A., Bhaumik, S., Basu, R., Sen, P.*, and Roy, S. (2010) Leishmania donovani isolates with antimony-resistant but not -sensitive phenotype inhibit sodium antimony gluconate-induced dendritic cell activation. PLoS Pathog. 6, e1000907; * Corresponding author.
• Manish Mishra, Manisha Yadav, Sandeep Kumar, Raj Kumar and Pradip Sen (2023). TIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3. Cell Death & Disease 14(5): 331.
• Manisha Yadav, Md. Naushad Akhtar, Manish Mishra, Sandeep Kumar, Raj Kumar, Shubham, Anil Nandal and Pradip Sen (2023). Leishmania donovani Attenuates Dendritic Cell Trafficking to Lymph Nodes by Inhibiting C-Type Lectin Receptor-2 Expression via TGF-. Microbiology Spectrum May 1: e0412222. (Md. Naushad Akhtar and Manish Mishra contributed equally) 
• Md. Naushad Akhtar, Sahil Kumar and Pradip Sen (2022). Leishmania donovani Impedes Antileishmanial Immunity by Suppressing Dendritic Cells via the TIM-3 Receptor. mBio 13 (4): e03309-21. 
• Prateek Singh, Rajat Ujjainiya, Satyartha Prakash, Salwa Naushin, ----- Pradip Sen, Rashmi Kumar, Ansh Buhardwaj, ----- Shantanu Sengupta, Debasis Dash (2022). A machine learning-based approach to determine infection status in recipients of     BBV152 (Covaxin) whole-virion inactivated SARS-CoV-2 vaccine for serological surveys. Computers in Biology and Medicine146: 105419. (PAN-CSIR Cohort study)
• Salwa Naushin, Viren Sardana, Rajat Ujjainiya, ----- Pradip Sen, Saumya Ray Chaudhury, Rashmi Kumar, Pawan Gupta, ------ Debasis Dash, Shantanu Sengupta (2021). Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2. eLife10: e66537. 

Lab Members