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Name:
Dr. Suresh Korpole
Expertise:
Prokaryotic diversity, systematics and their applications in biotechnology.

Contact Address:

Microbial Type Culture Collection & Genebank (MTCC)
Institute of Microbial Technology
Sector 39A, Chandigarh – 160036
India
Phone no: 0172-2636680-94 (Ext: 3155)
Email: suresh@imtech.res.in; korpole@gmail.com

Write-up of research and development interests/focus, past and present goals:

Microbial diversity studies of various aerobic and anaerobic ecosystems and their biotechnological applications

Prokaryotes are the dominant form of life on earth and they found to survive under any conditions of the biosphere. We are using an integrated approach to understand the nature of free-living prokaryotes by studying microbial diversity and their ecology. This information provides an insight into the systematics of these prokaryotes and their biotechnological applications. Microorganisms existing in complex environments often require capability to produce antimicrobial compounds as a competitive advantage to producing strains for their establishment in these ecosystems. Although many bacterial strains produce antimicrobial peptides as defensins, only few of them have been characterized in detail. Therefore, our laboratory mainly focused on isolation and characterization of novel antimicrobial peptides including different types of bacteriocins from microbial diversity of aerobic and anaerobic ecosystems. To this effect, we have characterized few antimicrobial peptides produced by strains of Brevibacillus laterosporus. Further antimicrobial peptides produced by other bacterial strains including Bacillus, Paenibacillus, Lactobacillus and Clostridium species are being investigated. The AMPs were purified by HPLC and characterized by MALDI MS/MS analysis. The analyses of the antimicrobial peptides suggested that these strains also produce antimicrobial lipopeptides. My lab is also actively involved in determination of total microbial diversity using both culturable and culture independent approaches. As a part of culturable diversity characterization, we have determined the taxonomic status of few novel prokaryotic strains as novel genera and species.


Significant recognition: Awards, fellowships, international funding of distinction, technologies transferred/licensed etc.:

  • DBT Biotechnology Overseas Associate (long-term/one year): To avail the award worked as an “Associate” with Prof. William B. Whitman at Department of Microbiology, University of Georgia, Athens, GA, USA.

Selected list of Publications and Patents:

Selected Publications:

  • Santi M. Mandal, Shalley Sharma, Anil Kumar Pinnka, Annu Kumari, Suresh Korpole* (2013). Isolation and characterization of diverse antimicrobial lipopeptides produced by Citrobacter and Enterobacter. BMC Microbiol, 13:152.
  • Piyush Baindara, Santi M. Mandal, Niharika Chawla, Pradip Kumar Singh, Ani Kumar Pinnka, Suresh Korpole (2013). Characterization of two antimicrobial peptides produced by a halotolerant Bacillus subtilis strain SK.DU.4 isolated from a rhizosphere soil sample. AMB Express 3:2.
  • Sukhpreet Kaur, Mir Yawar, P. Anil Kumar, K. Suresh (2013). Hungatella effluvii gen. nov., sp. nov. an obligate anaerobic bacterium isolated from effluent treatment plant and reclassification of Clostridium hathewayi as Hungatella hathewayi comb. nov. Int J Syst Evol Microbiol (In press) doi:10.1099/ijs.0.056986-0.
  • Mandal S.M., Porto W.F., De D., Phule A., Korpole S., Ghosh A.K., Roy S., Franco O.L. (2013). Screening of serine protease inhibitors with antimicrobial activity by iron oxide nanoparticles functionalized with dextran conjugated trypsin and in silico analyses of bacterial serine protease inhibition. Analyst, In-press doi:10.1039/C3AN01132A.
  • Pradip K. Singh, Chittpurna, Ashish, Vikas Sharma, Prabhu B. Patil and K. Suresh (2012). Identification, Purification and Characterization of Laterosporulin, a Novel Bacteriocin Produced by Brevibacillus sp. strain GI-9. PLoS ONE 7(3): e31498. doi:10.1371/journal.pone.0031498.
  • Krishnamurthi, S., Stefan Spring, Anil Kumar P., Mayilraj, S., Hans-Peter Klenk, Suresh, K. (2012). Desulfotomaculum defluvii sp. nov., a sulfate-reducing bacterium isolated from the subsurface environment of a landfill. Int J Syst Evol Micobiol.
  • Thomas J. Lie, Kyle C. Costa, Boguslaw Lupa, Suresh Korpole, William B. Whitman, and John A. Leigh (2012). Essential anaplerotic role for the energy-converting hydrogenase Eha in hydrogenotrophic methanogenesis. Proc. Natl. Acad. Sci. U.S.A. 109: 15473-15478 (doi:10.1073/pnas.1208779109).
  • Vikas Sharma, Pradip K. Singh, Samriti Midha, Manish Ranjan, Suresh Korpole and Prabhu B. Patil (2012). Genome sequence of Brevibacillus laterosporus strain GI-9. J Bacteriol 194(5): 1279. 


































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